The Mississippi Gulf Coast Chamber of Commerce is an organization made up of businesses, in Harrison County and throughout South Mississippi. Its main goal is to enhance the business environment by facilitating, advocating, and sharing information on behalf of the region. The chamber collaborates with the Biloxi Gulfport, Long Beach, and Pass Christian Chambers of Commerce to promote community and economic development on the Mississippi Gulf Coast.

Membership in the chamber comes with benefits such as networking opportunities, educational training programs, and exclusive discounts at Office Depot. Throughout the year there are events organized by the chamber including the Annual Awards Ceremony, Annual Golf Tournament, and Annual Business Expo. These events serve as platforms for businesses to showcase their offerings connect with enterprises and reach customers.