The Hancock County Chamber of Commerce holds the distinction of being the organization, in the county advocating for businesses. With a membership base exceeding 1,500 representatives from sectors including businesses, community partners, elected officials, young professionals, educators, non-profit organizations, and engaged citizens. The chamber's primary objective revolves around fostering connections among businesses and cultivating a community through initiatives like business retention and expansion workforce development, education, government relations relocation campaigns well as greenways and beautification efforts.

Being a member of this chamber comes with advantages. Members gain access to more than 150 events and meetings held throughout the year. They also have opportunities to actively contribute to chamber committees while benefiting from marketing avenues and advocacy endeavors. Notable events organized by the chamber include the Annual Chamber Awards Ceremony, the Annual Golf Tournament along the recurring Annual Business Expo. Moreover every Tuesday from August through December local small businesses extend their hours until 7;00 p.m. offering themed experiences and exciting random prize drawings during "After 5 Nights " which are supported by the chamber.