The Fayette County Chamber of Commerce is a non-profit organization that represents businesses, in the Fayette County area of West Virginia catering to businesses of all sizes and types. The Chamber acts as a representative for the community. Actively promotes the image, retention, and growth of existing businesses. It strives to enhance vitality and facilitate planned development in the region. Moreover, the Chamber provides an array of programs, services, and activities aimed at fostering progress within Fayette County.

Fayette County is a destination for adventure enthusiasts and entrepreneurs. It offers opportunities for pursuits such as hiking, biking, and rock climbing. The Chamber collaborates with community development agencies, local government bodies, and private organizations to undertake improvement projects. These initiatives include undertakings like the completion of transportation infrastructure like the Mon Fayette expressway; the development of a recreational walkway encircling Uniontown downtown area; conducting seminars for small business enhancements; serving as a liaison between officials and legislators; establishing partnerships between businesses and educational institutions for curriculum development, career guidance for students and overall enhancement of the school system.