The Delaware State Chamber of Commerce (DSCC) is the most influential business organization, in Delaware established in 1837 as the Wilmington Board of Trade. The main goal of the DSCC is to foster an environment that enhances the competitiveness of businesses in Delaware and brings benefits to its residents. The DSCC provides a range of services to its members acts as a source of information on issues impacting businesses of all sizes and represents the business community's interests when dealing with the government in Delaware.

On its website, the DSCC offers a directory of events and programs designed to support business growth and community development across Delaware. Throughout the year they organize events such as the Annual Dinner, Small Business Alliance Awards, and Superstars in Business Awards. Additionally being a member of the DSCC comes with advantages including access to resources like the DSCC Health Insurance Marketplace, DSCC Energy Program, and DSCC Workers Compensation Program.