The Clarksdale Coahoma County Chamber of Commerce has been actively supporting businesses and their interests, in Clarksdale and Coahoma County since 1917. The chamber organizes an array of programs and events while also being the sponsor of Clarksdales top notch music and cultural festivals. A dedicated team of volunteers leads the chamber generously donating their time and energy to offer the community experiences through programs and events ultimately enhancing the lives of residents and visitors in Clarksdale and Coahoma County.

Funding for the chamber comes from both business and individual memberships as substantial contributions from entities like the City of Clarksdale Clarksdale Public Utilities and the Economic Development Authority of Coahoma County. Throughout the year the chamber hosts events including its Annual Chamber Banquet, the Annual Christmas Parade and an exciting concert series called Fridays at the Stage. Moreover they proudly sponsor cultural festivals in Clarksdale such as the Juke Joint Festival along with the Sunflower River Blues & Gospel Festival.